Abstract #0682

How tumour pressure components are related to tumour blood perfusion and mechanical properties

Gwenaël Pagé¹, Marion Tardieu¹, Laurent Besret², Bernard Van Beers^1,3, and Philippe Garteiser¹

¹Laboratory of Imaging Biomarker, INSERM-University Paris Diderot, Paris, France, ²Sanofi, Vitry sur seine, France, ³Department of Radiology, Beaujon University Hospital Paris Nord, Clichy, France

The purpose of this study was to assess the influence of tumour pressure components (solid stress and IFP) on blood perfusion and mechanical properties. MR elastography and perfusion measurements (FAIR method) were performed in mice with tumours xenografted subcutaneously. Tumours pressure components were measured with a catheter-transducer system. The results suggest that solid stress is the major pressure component. Both solid and fluid pressures influence perfusion and by collapsing vessels could be obstacles to drug delivery. However, the MR elastography results suggest that increased solid stress and increased mechanical properties are two distinct tumour characteristics.

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