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Abstract #0683

Constant gradient magnetic resonance elastography experiments on phantom and bovine liver.

Pilar Sango Solanas1, Eric Van Reeth1, Pauline M. Lefebvre2, Hélène Ratiney1, Elisabeth Brusseau1, Denis Grenier1, Steffen J. Glaser3, Dominique Sugny4, Olivier Beuf1, and Kevin Tse-Ve-Koon1

1Univ Lyon, INSA‐Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1206, Lyon, France, 2Université de Toulouse, CNRS, INPT, UPS, IMFT, Toulouse, France, 3Department of Chemistry, Technische Universität München, Munich, Germany, 4ICB, CNRS UMR6303, Université de Bourgogne, Dijon, France

Magnetic Resonance Elastography (MRE) is performed by the application of motion-sensitive gradients. In this study, RF pulses are designed with an optimal control algorithm to obtain a desired magnetization phase distribution. Such pulse, in presence of a constant gradient, allows to simultaneously perform spatially selective excitation and motion encoding. This offers some advantages when compared to standard MRE encoding strategy. Simulations, phantom and ex vivo experiments show that phase-to-noise ratios are improved. These results demonstrate that optimal control-based pulses can be used to encode motion in the MRE excitation phase with relevant advantages for further in vivo liver rat studies.

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