Abstract #0687

Regional Variation of Water Permeability at the Blood-Brain Interface in the Mouse Brain using Multi-TE ASL: The Role of Aquaporin-4

Yolanda Ohene¹, Ian F. Harrison¹, Payam Nahavandi ¹, Ozama Ismail¹, Phoebe Evans ¹, Eleanor V. Bird¹, Ole P. Ottersen ², Erlend A Nagelhus³, David L Thomas ^4,5, Mark F Lythgoe¹, and Jack A Wells¹

¹UCL Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, ²Office of the President, Karolinska Institutet, Stockholm, Sweden, ³GliaLab and Letten Centre, University of Oslo, Oslo, Norway, ⁴Neuroradiological Academic Unit, UCL Institute of Neurology, University College London, London, United Kingdom, ⁵Leonard Wolfson Experimental Neurology Centre, UCL Institute of Neurology, University College London, London, United Kingdom

We apply a multi-TE ASL technique to the mouse brain to assess the regional variation of water permeability at the blood brain interface, and measure the expression of brain AQP4 water channels as a marker of water transport. We report a significant decrease in the intravascular fraction of the ASL signal in the cerebellum compared to the cortex, 0.61 (± 0.22) and 0.90 (± 0.08) respectively, which is consistent with a marked increase (~400%) in Aqp4 expression in the cerebellum. This technique is a promising tool to better understand the dynamic role of AQP4 in pathological conditions.

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