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Abstract #0687

Regional Variation of Water Permeability at the Blood-Brain Interface in the Mouse Brain using Multi-TE ASL: The Role of Aquaporin-4

Yolanda Ohene1, Ian F. Harrison1, Payam Nahavandi 1, Ozama Ismail1, Phoebe Evans 1, Eleanor V. Bird1, Ole P. Ottersen 2, Erlend A Nagelhus3, David L Thomas 4,5, Mark F Lythgoe1, and Jack A Wells1

1UCL Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 2Office of the President, Karolinska Institutet, Stockholm, Sweden, 3GliaLab and Letten Centre, University of Oslo, Oslo, Norway, 4Neuroradiological Academic Unit, UCL Institute of Neurology, University College London, London, United Kingdom, 5Leonard Wolfson Experimental Neurology Centre, UCL Institute of Neurology, University College London, London, United Kingdom

We apply a multi-TE ASL technique to the mouse brain to assess the regional variation of water permeability at the blood brain interface, and measure the expression of brain AQP4 water channels as a marker of water transport. We report a significant decrease in the intravascular fraction of the ASL signal in the cerebellum compared to the cortex, 0.61 (± 0.22) and 0.90 (± 0.08) respectively, which is consistent with a marked increase (~400%) in Aqp4 expression in the cerebellum. This technique is a promising tool to better understand the dynamic role of AQP4 in pathological conditions.

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