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Abstract #0692

Ultra-high temporal resolution on the inversion recovery curve: new insight into T1 relaxometry of the human brain

Ana-Maria Oros1, Anna Weglage1, and N. Jon Shah1,2,3,4

1Institute of Neuroscience and Medicine (INM-4), Research Centre Juelich, Juelich, Germany, 2JARA-BRAIN-Translational Medicine, Research Centre Juelich, Aachen, Germany, 3Institute of Neuroscience and Medicine (INM-11, JARA), Research Centre Juelich, Juelich, Germany, 4Department of Neurology, RWTH Aachen University, Aachen, Germany

Tissue T1 relaxation is considered to be monoexponential. This is, however, an assumption, since it is seldom measured with sufficiently dense sampling of the relaxation curve. We hypothesized that a spatially-resolved investigation of tissue T1 relaxation curve with ultra-high temporal resolution might reveal previously unidentified characteristics of this fundamental NMR parameter. We imaged 10 healthy volunteers using a Look-Locker sequence with 460 time points 17ms apart on the inversion recovery curve. Denoising using PCA and NNLS decomposition of the recovery curves revealed, among others, a moderately short T1 component (4-500ms) in both WM and GM, tentatively assigned to myelin water.

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