Current diagnosis of renal disease and injury relies on blood urea nitrogen and serum creatinine measurements, which provide generic information about kidney function but do not provide spatial specificity during kidney failure. Urea has previously been used as a vehicle for hyperpolarized MR imaging of renal function, and as a contrast agent of CEST MRI. Here, we examine whether injection of urea can provide CEST contrast for quantitation of renal integrity via probing the spatially varying urea concentrating capacity of a kidney.
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