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Abstract #0702

Free-breathing renal perfusion measurement with volumetric ASL using variable-density FSE and 4D Compressed-Sensing

Manuel Taso1, Arnaud Guidon2, Daniel V Litwiller3, and David C Alsop1

1Division of MRI research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boson, MA, United States, 2Global MR Applications and Workflow, GE Healthcare, Boston, MA, United States, 3Global MR Applications and Workflow, GE Healthcare, New York, NY, United States

While single or 2D multi-slice body ASL implementations have been shown to be compatible with free-breathing for abdominal perfusion measurement even in uncooperative clinical populations, free-breathing volumetric encoding has not been reported yet. We propose a free-breathing volumetric ASL acquisition relying on a motion-robust variable-density 3D-FSE sequence with redundant k-space center and pseudo-random variable outer k-space sampling and 4D-Parallel-Imaging-Compressed-Sensing reconstruction. High-quality whole kidneys perfusion images were obtained in less than 5 minutes in free-breathing, potentially extending the clinical applications of non-contrast ASL perfusion in the abdomen.

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