While single or 2D multi-slice body ASL implementations have been shown to be compatible with free-breathing for abdominal perfusion measurement even in uncooperative clinical populations, free-breathing volumetric encoding has not been reported yet. We propose a free-breathing volumetric ASL acquisition relying on a motion-robust variable-density 3D-FSE sequence with redundant k-space center and pseudo-random variable outer k-space sampling and 4D-Parallel-Imaging-Compressed-Sensing reconstruction. High-quality whole kidneys perfusion images were obtained in less than 5 minutes in free-breathing, potentially extending the clinical applications of non-contrast ASL perfusion in the abdomen.
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