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Abstract #0705

Time-efficient fully 3D non-Cartesian dynamic contrast-enhanced free-breathing MRI of the pelvis with an ultrashort TE cones trajectory

Signy Holmes1, Frank Ong2, Michael Lustig2, Ryan Brunsing1, Vipul R Sheth1, Marcus T Alley1, Michael Carl3, John M Pauly4, Joseph Y Cheng1, and Shreyas S Vasanawala1

1Radiology, Stanford University, Stanford, CA, United States, 2Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA, United States, 3Applied Science Laboratory, GE Healthcare, San Diego, CA, United States, 4Electrical Engineering, Stanford University, Stanford, CA, United States

A 3D cones k-space trajectory with golden angle ordering was developed along with a multiscale low rank reconstruction for dynamic contrast enhancement with ultrashort echo time (DCE-UTE) and with fast image reconstruction time. With IRB approval and informed consent the sequence was tested in 21 consecutive subjects referred for 3T contrast-enhanced pelvic MRI. For comparison, a Cartesian DCE SPGR sequence with golden angle radial k-space ordering, soft-gated self navigation, and low rank reconstruction (DCE-SPGR) served as case controls. DCE-UTE performed significantly better than DCE-SPGR in delineation of anatomic structures (p=0.004) and overall perceived image quality (p=0.003). These results indicate a 3D fully noncartesian DCE-UTE sequence and reconstruction improves image quality in pelvic DCE.

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