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Abstract #0713

Total suicide attempts associated with distinct functional neuroimaging correlates in bipolar disorder

Joseph James Shaffer1, Virginia L Willour2, Casey P Johnson1, Jeffrey D Long2, Jess G Fiedorowicz2, Gary E Christensen3, John A Wemmie2, and Vincent A Magnotta1

1Radiology, University of Iowa, Iowa City, IA, United States, 2Psychiatry, University of Iowa, Iowa City, IA, United States, 3Electrical and Computer Engineering, University of Iowa, Iowa City, IA, United States

Suicidal behavior is a major cause of injury and death in bipolar disorder. We measured the relationship between a history of suicide attempt and brain activation to a flashing checkerboard task in bipolar disorder using functional magnetic resonance imaging (fMRI). We compared activity between suicide attempters and non-attempters and we separately tested the relationship between brain activity and the number of past suicide attempts. These two analyses produced distinct patterns of results that indicated a mood-state independent relationship between suicide attempts and prefrontal and cerebellar activity. These findings suggest that accounting for multiple attempters may strengthen studies of suicidal behavior.

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