Meeting Banner
Abstract #0712

DRD2 TaqIA Polymorphism related Functional Connectivity Between Anterior Insula and Dorsolateral Prefrontal Cortex in Heroin-dependent Individuals under Methadone Maintenance Treatment Predicts Retention Time

Lei Wang1, Feng Hu2, and Yarong Wang3

1The First Affilicated Hospital of Xi'An JiaoTong University, Xi'an, China, 2Department of Radiology, The Hospital of Shannxi provincial geology and mineral resources bureau, Xi'an, China, 3Department of Radiology, The First Affilicated Hospital of Xi'An JiaoTong University, Xi'an, China

The present study adopted functional parcellation method to get functional-different subdivisions atlas of insula from healthy controls, and performed whole brain functional connectivty(FC) based on these subdivisions with resting-state fMRI data aquired from heroin-dependent participants under methadone maintantreatment (HDM). These HDM were grouped by DRD2 Taq1A polymorphism, and compared the FC differences of each insula subdivisions group-wise. Results showed the way DRD2 gene influence the FC between the left anterior insula and right dorsolateral prefrontal cortex. This gene-influenced FC further demonstrated its positive association with retention time, in a survival analysis.

This abstract and the presentation materials are available to members only; a login is required.

Join Here