The present study adopted functional parcellation method to get functional-different subdivisions atlas of insula from healthy controls, and performed whole brain functional connectivty(FC) based on these subdivisions with resting-state fMRI data aquired from heroin-dependent participants under methadone maintantreatment (HDM). These HDM were grouped by DRD2 Taq1A polymorphism, and compared the FC differences of each insula subdivisions group-wise. Results showed the way DRD2 gene influence the FC between the left anterior insula and right dorsolateral prefrontal cortex. This gene-influenced FC further demonstrated its positive association with retention time, in a survival analysis.
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