Abstract #0711

Surface-based diffusion MRI analysis of the superficial white matter in autism: association with functional networks and symptom severity

Seok-Jun Hong^1,2, Hyung Brian¹, Shahin Tavakol¹, Alexander Lowe¹, Sara Lariviere¹, Reinder Vos De Wael¹, Casey Paquola¹, and Boris C. Bernhardt¹

¹Multimodal Imaging and Connectome Analysis Lab, Montreal Neurological Institute, Montreal, Quebec, QC, Canada, ²Center for the Developing Brain, Child Mind Institute, New York, NY, United States

Our study focused on a region that remains relatively unexplored by autism neuroimaging: the superficial white matter (SWM) immediately beneath the cortical interface, a compartment known to play a key role in corticogenesis and connectivity. A surface-based diffusion-MRI analysis revealed SWM anomalies in a multicentric ASD cohort compared to neurotypical controls in medial parietal and temporo-parietal regions. Notably, structural anomalies were found to modulate functional connectivity reductions in ASD and related to symptom severity. Analyses targeting the SWM offer a novel perspective on the interplay between structural and functional network perturbations in ASD.

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