Arginase-2 is upregulated following renal injury. This study used hyperpolarized pyruvate, arginine, citrulline and γ-glutamylglycine to probe changes in renal metabolism following ischemia-reperfusion in mice deficient in renal arginase-2. The kidney is a major site of arginine synthesis, and conversion of hyperpolarized citrulline to arginine can be detected, as can a signal consistent with argininosuccinate. While metabolic differences in mice lacking arginase-2 compared to controls are not readily apparent by this method, ischemia has a clear effect on several metabolite signals. Of the pyruvate metabolites, conversion to aspartate is significantly diminished, as is arginine and argininosuccinate production from citrulline.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords