Hyperpolarized (HP) [1-13C]pyruvate [1] has been widely exploited for the metabolic processes. The development of this agent has enabled the in vitro and in vivo real-time detection of pyruvate-lactate metabolic conversion. The possibility of obtaining HP pyruvate using the cost effective and fast PHIP (ParaHydrogen Induced Polarization) method, instead of the dissolution Dynamic Nuclear Polarization (d-DNP), would allow a widespread application of this powerful diagnostic tool, that so far has been hampered by cost, technical complexity and intrinsically low polarization time. Here we report an in vitro and in vivo study carried out on different cancer cell lines and in vivo using PHIP-SAH HP-[1-13C]pyruvate.
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