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Abstract #0719

Hyperpolarized [1-13C] Alanine Ethyl Ester for Assessment of Hepatic Alanine Metabolism

Jun Chen1, Edward P Hackett1, Richard Martin1, Zoltan Kovacs1, and Jae Mo Park1,2,3

1Advanced Imaging Research Center, UT Southwestern Medial Center at Dallas, Dallas, TX, United States, 2Radiology, UT Southwestern Medical Center at Dallas, Dallas, TX, United States, 3Electrical Engineering, University of Texas at Dallas, Dallas, TX, United States

[1-13C] alanine ethyl ester was studied as hyperpolarized substrate to measure the alanine metabolism in rat liver. The results show that [1-13C] alanine ethyl ester enters the cell converts to [1-13C] lactate more efficiently. Therefore, [1-13C] alanine ethyl ester is a potential compound to assess hepatic alanine metabolism with improved sensitivity.

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