Abstract #0719

Hyperpolarized [1-13C] Alanine Ethyl Ester for Assessment of Hepatic Alanine Metabolism

Jun Chen¹, Edward P Hackett¹, Richard Martin¹, Zoltan Kovacs¹, and Jae Mo Park^1,2,3

¹Advanced Imaging Research Center, UT Southwestern Medial Center at Dallas, Dallas, TX, United States, ²Radiology, UT Southwestern Medical Center at Dallas, Dallas, TX, United States, ³Electrical Engineering, University of Texas at Dallas, Dallas, TX, United States

[1-¹³C] alanine ethyl ester was studied as hyperpolarized substrate to measure the alanine metabolism in rat liver. The results show that [1-¹³C] alanine ethyl ester enters the cell converts to [1-¹³C] lactate more efficiently. Therefore, [1-¹³C] alanine ethyl ester is a potential compound to assess hepatic alanine metabolism with improved sensitivity.

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