Abstract #0720

Mildronate Modulates In-Vivo Metabolism and Improves Ex-Vivo Functional Recovery Post-ischemia in the Diabetic Heart

Dragana Savic¹, David Hauton¹, Lorenz Holzner², Vicky J. Ball¹, Lisa Heather¹, and Damian J. Tyler¹

¹University of Oxford, Oxford, United Kingdom, ²University of Cambridge, Cambridge, United Kingdom

Carnitine acts as a buffer of acetyl-CoA units in the mitochondria, as well as facilitating transport of fatty acids. Mildronate can block the biosynthesis of L-carnitine, reducing the uptake of fatty acids into the mitochondria by CPT-1. The purpose of this study was to investigate the effect of Mildronate treatment on cardiac function and metabolism in the healthy and diabetic rat heart. We showed that daily injections of Mildronate can alter cardiac metabolism in the in vivo diabetic and healthy rat heart, without any functional changes. However, when exposed to ischemia ex-vivo, Mildronate treated hearts improve their functional recovery post-ischemia. Such studies allow a better understanding of the interactions between metabolism and function in the diabetic heart and may provide new insight into novel therapeutics.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.