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Abstract #0721

Longitudinal Hyperpolarized 13C Imaging of Metabolic Changes Following Myocardial Infarction in Pigs

Maximilian Fuetterer1, Julia Traechtler1, Julia Busch1, Andreas Dounas1, Sophie M Peereboom1, Mareike Gastl1,2,3, Mareike Sauer4, Miriam Lipiski4, Thea Fleischmann4, Nikola Cesarovic4, Christian T Stoeck1, and Sebastian Kozerke1

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland, 3Department Cardiology, Pneumology and Angiology, Heinrich Heine University, Duesseldorf, Germany, 4Division of Surgical Research, University Hospital Zurich, Zurich, Switzerland

The heart’s dynamic, bimodal response to myocardial infarction warrants longitudinal study designs to better understand the interplay between perfusion deficits, metabolic processes and function. To this end, a longitudinal study over 12 weeks was set up to probe myocardial metabolism post-infarction in an infarct pig model using hyperpolarized [13C]-pyruvate. Image acquisition was optimized for improved spatial and temporal image fidelity based on spectrally-selective excitation and EPI readouts. Initial results demonstrate good agreement with supplementary gadolinium enhanced imaging and indicate a temporal metabolic shift towards increased lactate-to-bicarbonate ratios in the lesion territory caused by cardiac infarction.

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