Abstract #0725

Hyperpolarized 13C Metabolic Imaging of a Renal Cell Carcinoma Patient with Brain Metastasis

Casey Y. Lee^1,2, Hany Soliman³, Benjamin J. Geraghty^1,2, Albert P. Chen⁴, Nadia D. Bragagnolo^1,2, William J. Perks⁵, and Charles H. Cunningham^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ³Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁴GE Healthcare Technologies, Toronto, ON, Canada, ⁵Pharmacy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

The application of hyperpolarized ¹³C MRI to non-invasively acquire metabolic images of [1-¹³C]lactate and ¹³C-bicarbonate from the injected [1-¹³C]pyruvate in the brain of metastatic renal cell carcinoma patient, as well as that of 7 healthy volunteers are investigated. Elevated [1-¹³C]lactate and [1-¹³C]pyruvate signals were observed from the metastasis, as well as high lactate-to-bicarbonate ratio. The clinical history of the patient suggests that the elevated signals observed in the metastasis may be reflecting the progressive state of the patient’s disease.

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