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Abstract #0725

Hyperpolarized 13C Metabolic Imaging of a Renal Cell Carcinoma Patient with Brain Metastasis

Casey Y. Lee1,2, Hany Soliman3, Benjamin J. Geraghty1,2, Albert P. Chen4, Nadia D. Bragagnolo1,2, William J. Perks5, and Charles H. Cunningham1,2

1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 3Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 4GE Healthcare Technologies, Toronto, ON, Canada, 5Pharmacy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

The application of hyperpolarized 13C MRI to non-invasively acquire metabolic images of [1-13C]lactate and 13C-bicarbonate from the injected [1-13C]pyruvate in the brain of metastatic renal cell carcinoma patient, as well as that of 7 healthy volunteers are investigated. Elevated [1-13C]lactate and [1-13C]pyruvate signals were observed from the metastasis, as well as high lactate-to-bicarbonate ratio. The clinical history of the patient suggests that the elevated signals observed in the metastasis may be reflecting the progressive state of the patient’s disease.

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