Abstract #0724

First Hyperpolarized [2-13C]Pyruvate MR Studies of Human Brain Metabolism

Brian T Chung^1,2, Hsin-Yu Chen¹, Jeremy Gordon¹, Daniele Mammoli¹, Renuka Sriram¹, Adam Autry¹, Lydia Le Page^1,3, Myriam Chaumeil^1,3, Peter Shin¹, James Slater¹, Chou T Tan⁴, Chris Suszczynski⁴, Susan Chang⁵, Robert Bok¹, Sabrina Ronen^1,2, Peder EZ Larson^1,2, John Kurhanewicz^1,2, and Daniel B Vigneron^1,2

¹Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²UCSF – UC Berkeley Graduate Program in Bioengineering, University of California, San Francisco, CA, United States, ³Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA, United States, ⁴ISOTEC Stable Isotope Division, MilliporeSigma, Merck KGaA, Miamisburg, OH, United States, ⁵Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States

We investigated hyperpolarized (HP) [2-¹³C]pyruvate conversion to [2-¹³C]lactate and [5-¹³C]glutamate for the first time in the healthy human brain, with a focus on the development of hyperpolarization and preparation techniques for sterile [2-13C]pyruvate with FDA-IND & IRB approval. HP [2-¹³C]pyruvate, [2-¹³C]lactate, [5-¹³C]glutamate and other metabolites were successfully observed and quantitatively measured for the first time in four volunteers, and initial EPI studies confirmed a feasibility of imaging [2-¹³C]pyruvate to [5-¹³C]glutamate conversion, demonstrating a significant first step for HP metabolic imaging to diagnose and detect early stage neurological disorders.

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