Abstract #0723

Metabolic imaging of brain inflammation using hyperpolarized 13C MRSI of pyruvate and urea in a mouse model of multiple sclerosis

Caroline Guglielmetti^1,2, Christian Cordano³, Chloe Najac⁴, Ari Green^3,5, and Myriam M. Chaumeil^1,2

¹Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA, United States, ²Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ³Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California San Francisco, San Francisco, CA, United States, ⁴Department of Radiology, C.J. Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, Netherlands, ⁵Department of Ophthalmology, University of California San Francisco, San Francisco, CA, United States

We used conventional MRI and hyperpolarized ¹³C magnetic resonance spectroscopy (HP ¹³C MRSI) quantitative imaging of pyruvate and urea to assess lesion pathology and the metabolic signature in a model of multiple sclerosis (MS). T₂sequences detected white matter lesions and gadolinium-enhanced MRI showed blood-brain-barrier breakdown. HP ¹³C MRSI revealed increased lactate production and lactate-to-pyruvate ratios while urea levels remained unchanged. This is consistent with macrophage/monocyte infiltration into the CNS found in the model. Altogether, these findings demonstrate that HP ¹³C MRSI has potential to monitor macrophage infiltration and innate immune activation in inflammatory diseases of the central nervous system.

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