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Abstract #0739

Recovery of cerebrovascular reactivity after asymptomatic carotid artery stenosis treatment is assessable by Breathhold-fMRI within global watershed areas

Stephan Kaczmarz1,2, Jens Goettler1,2,3, Nico Sollmann1, Jan Kufer1, Mikkel Bo Hansen4, Andreas Hock5, Christian Sorg1, Claus Zimmer1, Kim Mouridsen4, Fahmeed Hyder2, Christine Preibisch1,6, and Jan Petr7

1Department of Neuroradiology, Technical University of Munich, Munich, Germany, 2MRRC, Yale University, New Haven, CT, United States, 3Clinic for Radiology, Technical University of Munich, Munich, Germany, 4Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark, 5Philips Healthcare, Hamburg, Germany, 6Clinic for Neurology, Technical University of Munich, Munich, Germany, 7Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany

Asymptomatic unilateral internal carotid-artery stenosis (ICAS) causes complex and currently poorly understood hemodynamic impairments which could possibly improve treatment decisions. Cerebrovascular reactivity (CVR) is an important biomarker of vascular health and can potentially serve to evaluate ICAS-treatment efficacy. We present perfusion MRI-data from a longitudinal study in 16 asymptomatic ICAS-patients before and after treatment plus 17 age-matched healthy controls. We hypothesize that CVR impairments in ICAS and their recovery after treatment can be assessed by Breathhold-fMRI analyzed by a data-driven approach. Our results demonstrate statistically significant CVR impairments within global watershed areas before treatment and significant CVR recovery after treatment.

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