Abstract #0739

Recovery of cerebrovascular reactivity after asymptomatic carotid artery stenosis treatment is assessable by Breathhold-fMRI within global watershed areas

Stephan Kaczmarz^1,2, Jens Goettler^1,2,3, Nico Sollmann¹, Jan Kufer¹, Mikkel Bo Hansen⁴, Andreas Hock⁵, Christian Sorg¹, Claus Zimmer¹, Kim Mouridsen⁴, Fahmeed Hyder², Christine Preibisch^1,6, and Jan Petr⁷

¹Department of Neuroradiology, Technical University of Munich, Munich, Germany, ²MRRC, Yale University, New Haven, CT, United States, ³Clinic for Radiology, Technical University of Munich, Munich, Germany, ⁴Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁵Philips Healthcare, Hamburg, Germany, ⁶Clinic for Neurology, Technical University of Munich, Munich, Germany, ⁷Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany

Asymptomatic unilateral internal carotid-artery stenosis (ICAS) causes complex and currently poorly understood hemodynamic impairments which could possibly improve treatment decisions. Cerebrovascular reactivity (CVR) is an important biomarker of vascular health and can potentially serve to evaluate ICAS-treatment efficacy. We present perfusion MRI-data from a longitudinal study in 16 asymptomatic ICAS-patients before and after treatment plus 17 age-matched healthy controls. We hypothesize that CVR impairments in ICAS and their recovery after treatment can be assessed by Breathhold-fMRI analyzed by a data-driven approach. Our results demonstrate statistically significant CVR impairments within global watershed areas before treatment and significant CVR recovery after treatment.

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