Abstract #0745

Characterization of Lenticulostriate Arteries using High-resolution 3D Black Blood MRI and Subcortical CBF using 3D pCASL as a Biomarker in Vascular Cognitive Impairment and Dementia

Samantha Jenny Ma¹, Kay Jann¹, Giuseppe Barisano¹, Xingfeng Shao¹, Lirong Yan¹, Marlene Casey¹, Lina D'Orazio², John M. Ringman², and Danny JJ Wang¹

¹Stevens Institute of Neuroimaging and Informatics, University of Southern California, Los Angeles, CA, United States, ²Neurology, University of Southern California, Los Angeles, CA, United States

Lenticulostriate arteries (LSAs) with small diameters of 280-510 µm take origin directly from the high flow middle cerebral artery (MCA), making them especially susceptible to damage by small vessel disease (SVD). In this study, we characterized the morphology of LSAs using High-resolution 3D Black Blood MRI and measured CBF in the MCA perforator territory (MCAperf) using 3D pCASL in a cohort of elderly Latino subjects. Our results show that the product of LSA delineation rating and MCAperf CBF are positively correlated with cognitive functions, and are reduced in subjects with mild cognitive impairment and hyperlipidemia.

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