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Abstract #0746

High resolution T2-prepared MRI enables non-invasive assessment of CSF flow in perivascular spaces of the human brain

Lydiane Hirschler1, Roxana Aldea2, Léonie Petitclerc1, Itamar A Ronen1, Patrick JH de Koning3, Mark A van Buchem1, and Matthias JP van Osch1

1Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Mathematical Sciences, University of Southampton, Southampton, United Kingdom, 3LKEB, Leiden University Medical Center, Leiden, Netherlands

Recently, flow of cerebrospinal fluid (CSF) has been shown to play an important role in the transport of brain metabolites, ushering in the concepts of glymphatics and intramural periarterial drainage. Failure of waste-drainage has been linked to incurable neurodegenerative diseases such as Alzheimer’s disease and cerebral amyloid angiopathy. The lack of a non-invasive imaging technique for the investigation of perivascular drainage mechanisms in the human brain strongly hinders the assessment of brain clearance in human subjects. In this study, we present the first non-invasive technique to visualize the CSF-flow along the middle cerebral artery (MCA), as well as along perivascular spaces of smaller arteries in the human brain.

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