Recently, flow of cerebrospinal fluid (CSF) has been shown to play an important role in the transport of brain metabolites, ushering in the concepts of glymphatics and intramural periarterial drainage. Failure of waste-drainage has been linked to incurable neurodegenerative diseases such as Alzheimer’s disease and cerebral amyloid angiopathy. The lack of a non-invasive imaging technique for the investigation of perivascular drainage mechanisms in the human brain strongly hinders the assessment of brain clearance in human subjects. In this study, we present the first non-invasive technique to visualize the CSF-flow along the middle cerebral artery (MCA), as well as along perivascular spaces of smaller arteries in the human brain.
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