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Abstract #0747

A Novel MRI Phantom to Study Interstitial Fluid Transport in the Glymphatic System

Michal E Komlosh1,2, Dan Benjamini1,2, Nathan H Williamson1, Ferenc Horkay1, Elizabeth B Hutchinson2,3, and Peter J Basser1

1NICHD, NIH, Bethesda, MD, United States, 2CNRM, USUHS, Bethesda, MD, United States, 3NIBIB, NIH, Bethesda, MD, United States

The glymphatic system transports cerebral spinal fluid throughout the brain to clear metabolic and cellular waste during sleep. While there is growing recognition of the critical role this system plays in maintaining normal brain health and in explaining pathology, there are no known noninvasive imaging methods to measure and characterize the efficacy of glymphatic transport in vivo. In this study, we designed, constructed, and tested a glymphatic transport magnetic resonance imaging (MRI) flow phantom. Using it, we determined it may be possible to detect interstitial glymphatic flows via diffusion MRI acquisition methods.

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