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Abstract #0768

High-fidelity, high-isotropic resolution diffusion imaging through gSlider acquisition with B1+ & T1 corrections and multi-coil B0 shim array

Congyu Liao1,2, Jason Stockmann1,2, Qiyuan Tian1,2, Berkin Bilgic1,2, Mary Kate Manhard1,2, Lawrence L Wald1,2, and Kawin Setsompop1,2

1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Department of Radiology, Harvard Medical School, Charlestown, MA, United States

gSlider is an SNR-efficient simultaneous multi-slab acquisition that has shown great potential for high-resolution diffusion imaging (DI). In this work, approaches to improve the fidelity of gSlider are proposed. A modified reconstruction which incorporates B1+ inhomogeneity and T1 recovery information was developed and demonstrated to successfully mitigate slab-boundary artifacts in short-TR gSlider acquisitions. Slice-by-slice B0-shimming through multi-coil shim-array, and high in-plane acceleration through virtual-coil GRAPPA were also incorporated into the acquisition and demonstrated to achieve 8-11x reduction in B0 distortion in single-shot EPI. The modified gSlider acquisition/reconstruction was used to acquire high-fidelity whole-brain 1mm isotropic DI with 64 diffusion-directions in 20-minutes at 3T.

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