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Abstract #0776

Quantitative Magnetization Transfer Imaging of Human Myocardial Tissue and Scar

Karina Lopez1, Radhouene Neji1,2, Imran Rashid1, Shaihan J Malik1, Rui Pedro AG Teixeira1, Reza Razavi1, Claudia Prieto1, Sebastien Roujol1, and Rene M Botnar1

1King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom

We have developed a contrast-free single breath-hold 2D MT mapping technique using a two-pool exchange model and dictionary matching to parametrize macromolecular changes associated with myocardial fibrosis. The model was validated in vials with different albumin concentrations and bovine leg. Pool sizes ratio and bound pool T2 maps were obtained from 7 healthy subjects and two patients with ischemic or non-ischemic scar/fibrosis. . Reduced PSR and T2B values were found to correlate with LGE areas in both patients. In vivo quantitative MT mapping of the heart was performed for the first time, showing promising results for the detection of myocardial fibrosis.

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