Diffusion Tensor Cardiovascular Magnetic Resonance (DT-CMR) is a promising contrast-free and non-invasive technique to characterize the tissue integrity and microstructure of the myocardium. However, the complex acquisition protocol results in prolonged scan times and often results in images with low spatial resolution and relatively poor signal-to-noise ratio. Here a novel ROI focused multi-scale super-resolution approach is proposed to improve the apparent spatial resolution of in vivo DT-CMR. Based on simulation studies, our proposed method can achieve increases in apparent spatial resolution by a factor of 4 with preserved image quality and no obvious degradation in the derived DT-CMR parameters.
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