Water/fat 2D LGE imaging has shown promising results for assessment of fibro-fatty infiltration in the myocardium and characterisation of cardiac masses. However, spatial resolution and volumetric coverage within a clinically feasible scan time remain a challenge. Here we propose a highly efficient respiratory motion-compensated 3D whole-heart water/fat inversion recovery (IR)-prepared LGE imaging sequence. Preliminary results from patients with cardiovascular disease demonstrate the feasibility of the approach, with scan duration of ~8 min. Motion-compensated 3D LGE water images offer a good depiction of myocardial scar, while motion-compensated fat images offer complementary diagnostic information, with clear delineation of epicardial and pericardial fat.