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Abstract #0783

Heartbeat-to-Heartbeat Quantitative Myocardial Oxygenation Imaging within a Single Breath-Hold using a Combined Gradient Echo-Spin Echo EPI (GESE-EPI) Sequence in Patients with Hypertension

Maaike van den Boomen1,2, Gert Jan H. Snel2, Christopher Nguyen1,3,4, Mary Kate Manhard1, David Sosnovik1,3,4, Rudi A.J.O. Dierckx2,5, Ciprian Catana1,6, David Izquerdo-Garcia1,6, Bruce R. Rosen1,6, Niek H.J. Prakken2, Ronald J.H. Borra5,7, and Kawin Setsompop1,6,8

1A.A. Martinos Center for Biomedical Imaging, Boston, MA, United States, 2Department of Radiology, University Medical Center Groningen, Groningen, Netherlands, 3Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States, 4Medicine, Harvard Medical School, Boston, MA, United States, 5Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, Netherlands, 6Department of Radiology, Harvard Medical School, Boston, MA, United States, 7Medical Imaging Centre of Southwest Finland, Turku University Hospital, Turku, Finland, 8Division of Health Sciences and Technology, Harvard-MIT, Cambridge, MA, United States

Dynamic Cardiac BOLD imaging techniques can suffer from signal variabilities due to changes in heartrate during a breath-hold. We demonstrate that a 2-echo-GESE-EPI sequence can provide T2- and T2*-weighted images simultaneously per heartbeat, but the dynamic changes in these images represent physiological effects mixed with heartrate changes. We then proposed a 5-echo-GESE-EPI for dynamic T2- and T2*-mapping per heartbeat as a readout for myocardial oxygenation. These dynamically acquired T2- and T2*-values were demonstrated to increase over the time of a breath-hold for healthy volunteers, while shown to remain constant and even reverse in hypertension patients.

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