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Abstract #0822

Multimodality OATP1B3-enhanced reporter gene imaging of engineered cells via fluorescence, photoacoustic, and magnetic resonance imaging

Nivin N Nyström1,2, Lawrence Yip2,3, Jeffrey Carson2,3, Timothy J Scholl1,2, and John A Ronald1,2

1Medical Imaging Laboratories, Robarts Research Institute, London, ON, Canada, 2Medical Biophysics, University of Western Ontario, London, ON, Canada, 3Lawson Health Research Institute, London, ON, Canada

Reporter genes can generate information on cell fate in vivo. Multimodality imaging can mitigate limitations of individual imaging modalities; thus, multimodality reporters are highly sought. We present a trimodality reporter gene system based on human Organic Anion-Transporting Polypeptide 1b3 (Oatp1b3) and its ability to take up indocyanine green (ICG) for fluorescence and photoacoustic imaging, as well as gadolinium ethoxy benzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) for MRI. This technology should find utility in tracking cell- and gene-based therapies for preclinical studies, and due to the human-derivation of the reporter gene and already clinically-utilized probes, presents with high translational potential.

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