Abstract #0823

Chimeric Mouse Model for MRI Contrast Agent Evaluation

Faryal F Mir^1,2, Ryan P Tomaszewski¹, Dorela D Shuboni-Mulligan¹, Christiane L Mallett¹, Jeremy M.L. Hix¹, Nicholas D Ether³, and Erik Shapiro^1,2

¹Department of Radiology, Michigan State University, East Lansing, MI, United States, ²Institute of Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, United States, ³Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, United States

While rodents are the primary models for contrast agent evaluation, there is considerable variability in pharmacokinetics of contrast agents in mice vs humans. OATPs play a role in in vivo pharmacokinetics in mice and humans. This study provides evidence that the OATP1B1/1B3 knock-in mouse is a more useful screening tool for novel MRI contrast agents destined for clinical use as compared to the traditionally used wild-type models.

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