Abstract #0824

MEMRI Can Quantify Myocardial Infarct Size Earlier Than LGE-MRI

Nur Hayati Jasmin^1,2, May Zaw Thin¹, Valerie Taylor¹, Christopher S Pope¹, Mark F Lythgoe¹, Sean Davidson³, and Daniel J Stuckey¹

¹Division of Medicine, Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, ²School of Medical Imaging, Universiti Sultan Zainal Abidin, Terengganu Darul Iman, Malaysia, ³Hatter Cardiovascular Institute, University College London, London, United Kingdom

Late gadolinium enhanced MRI (LGE-MRI) is an established method for quantification of infarct size after myocardial infarction but is non-specific and reflects the increased membrane rupture and extracellular volume (ECV) that occurs several hours after myocardial infarction. Manganese (Mn²⁺) is an efficient intracellular MR contrast agent, which acts as an analogue of Calcium (Ca²⁺) and can provide information on cell viability. The present study shows that manganese-enhanced MRI (MEMRI) can quantify the final infarct size earlier than LGE-MRI.

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