Abstract #0825

Magnetic resonance molecular imaging of EDB fibronectin with a ZD2 peptide Gd(HP-DO3A) conjugate for detecting pancreatic cancer

Peter Qiao¹, Nadia Ayat¹, Amita Vaidya¹, Songqi Gao¹, Han Zheng², Samuel Chou¹, and Zheng Rong Lu¹

¹Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Radiology, Johns Hopkins University, Baltimore, MD, United States

Pancreatic cancer (PC) carries a poor prognosis, partially due to lack of early diagnosis. To address this unmet need, the potential of magnetic resonance molecular imaging of extradomain B fibronectin with an oligopeptide targeted MRI contrast agent was assessed in mouse models of PC. Four PC cell lines were assayed for EDB-FN expression in vitro and found to overexpress EDB-FN. Analysis of ZD2 binding and contrast enhanced MRI demonstrated over two-fold improvement in CNR compared to non-targeted gadoteridol, with little non-specific binding. Histological analysis revealed the expression of EDB-FN in the tumor microenvironment and confirmed the features observed on MRI

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