Meeting Banner
Abstract #0825

Magnetic resonance molecular imaging of EDB fibronectin with a ZD2 peptide Gd(HP-DO3A) conjugate for detecting pancreatic cancer

Peter Qiao1, Nadia Ayat1, Amita Vaidya1, Songqi Gao1, Han Zheng2, Samuel Chou1, and Zheng Rong Lu1

1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Radiology, Johns Hopkins University, Baltimore, MD, United States

Pancreatic cancer (PC) carries a poor prognosis, partially due to lack of early diagnosis. To address this unmet need, the potential of magnetic resonance molecular imaging of extradomain B fibronectin with an oligopeptide targeted MRI contrast agent was assessed in mouse models of PC. Four PC cell lines were assayed for EDB-FN expression in vitro and found to overexpress EDB-FN. Analysis of ZD2 binding and contrast enhanced MRI demonstrated over two-fold improvement in CNR compared to non-targeted gadoteridol, with little non-specific binding. Histological analysis revealed the expression of EDB-FN in the tumor microenvironment and confirmed the features observed on MRI

This abstract and the presentation materials are available to members only; a login is required.

Join Here