The objective of this study was to determine if a feedback circuit between CSF production and arterial health may exist in the human brain. Sequential measurements of CSF volume were obtained, as well as cortical and choroid plexus function measured from pseudo-continuous arterial spin labeling (pCASL) before and after clinically-indicated indirect surgical revascularization. Regression analyses were used to evaluate dependence of study parameters on time. Following surgically-induced angiogenesis, fronto-parietal perfusion increased, which paralleled a reduction in choroid plexus perfusion. This could reflect a homeostatic mechanism where improved perivascular flow and more robust waste clearance prompts decreased choroid plexus CSF production.
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