The microcirculation of cerebral cortex has been investigated by anatomical studies in animals and human brain tissue. For the first time, we applied high resolution (0.5x0.5x1.4mm3) pulsed and pseudo-continuous ASL (pCASL) with inner-volume GRASE readout at 7T to measure CBF in the superficial, middle and deep layers of human cerebral cortex. Our results show higher perfusion in the middle layer using pCASL, while perfusion in the superficial layer of PASL may be affected by pial artery signals. In vivo imaging of layer dependent CBF opens door to investigating neurovascular coupling in a laminar fashion.
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