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Abstract #0850

An Extracorporeal Circulation Mouse Model for Simultaneous Measurements of Dynamic Contrast-Enhanced Arterial Input Functions and Radiotracer Blood Concentrations

Philipp Backhaus1,2,3, Florian Büther1, Lydia Wachsmuth3, Lynn Frohwein2, Klaus Schäfers2, Sven Hermann2, Michael Schäfers1,2, and Cornelius Faber3

1Department of Nuclear Medicine, University of Münster, Münster, Germany, 2European Institute for Molecular Imaging - EIMI, University of Münster, Münster, Germany, 3Translational Research Imaging Center - TRIC, University of Münster, Münster, Germany

Quantification of the arterial input function (AIF) in small animals is challenging in both dynamic contrast-enhanced (DCE)-MRI and in radiotracer studies. We present a novel extracorporeal circulation mouse model for DCE-measurements of the AIF in mice. The approach allows parallel measurement of tissue contrast dynamics as well as of radiotracer AIF using a β-microprobe integrated into the extracorporeal circulation.

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