Abstract #0851

Association between tumor acidity and hypervascularity within human gliomas using pH-weighted amine chemical exchange saturation transfer echoplanar imaging (CEST-EPI) and dynamic susceptibility contrast (DSC) perfusion MRI at 3T

Yulin Wang¹, Jingwen Yao^2,3,4, Ararat Chakhoyan^2,4, Catalina Raymond^2,4, Noriko Salamon⁴, Linda Liau^5,6, Phioanh Nghiemphu⁷, Albert Lai^6,7, Whitney Pope⁴, Timothy Cloughesy⁷, and Benjamin Ellingson^2,3,4,6,8,9

¹Department of Radiology, People’s Liberation Army General Hospital, Beijing, China, ²Brain Tumor Imaging Laboratory (BTIL), Center of Computer Vision and Imaging Biomarker, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ³Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA, United States, ⁴Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ⁵Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ⁶UCLA Brain Research Institute (BRI), David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ⁷Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ⁸Physics and Biology in Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ⁹Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States

In the current study, we employed a fast pH-weighted molecular MRI technique using amine chemical exchange saturation transfer echoplanar imaging (CEST-EPI) and compared to dynamic susceptibility contrast (DSC) perfusion MRI, in order to examine the association between tumor acidity and vascularity in 82 patients with histologically confirmed gliomas. We observed colocalized regions of altered vascularity and acidity in tumors within individual patients, and significant positive correlation between median magnetization transfer ratio asymmetry (MTR_asym) at 3ppm and relative cerebral blood volume (rCBV) within T₂hyperintense lesions. But areas of contrast enhancement were more complex and did not show a strong, predictable relationship.

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