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Abstract #0852

Evaluating white matter microstructure in childhood brain tumour survivors: A combined DTI and MTR approach.

Logan Richard1, Jovanka Skocic1, Ashley Ferkul1, Elizabeth Cox1,2, Suzanne Laughlin1, Eric Bouffet1, and Donald Mabbott1,2

1The Hospital for Sick Children, Toronto, ON, Canada, 2University of Toronto, Toronto, ON, Canada

Diffusion tensor imaging has been utilized to study the impact of cancer treatment on white matter microstructure in paediatric brain tumour survivors. We utilized magnetization transfer imaging (MTI), which provides more specific information on myelin, along with DTI, to determine if treatment for paediatric brain tumours has specific or non-specific impacts on white matter structure. When compared to their healthy counterparts, children treated for brain tumours exhibit decreased anisotropy and increased diffusion metrics without any significant differences in MT. This suggests treatment may impact fiber organization rather than myelin structure in this patient population.

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