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Abstract #0853

Glutamine Mediated Citrate Elevation- A ‘Metabolic-Rearrangement’ for Proliferation in High Grade Tumors: In vivo MRS Studies at 3T

Vivek Tiwari1, Zhongxu An1, Sandeep K Ganji2, Elena V Daoud1, Kimmo J. Hatanpaa1, Michael Levy1, Toral R Patel1, Elizabeth A Maher1, Edward Pan1, Bruce E Mickey1, and Changho Choi1

1UT Southwestern Medical Center, Dallas, TX, United States, 2Philips Healthcare, Andover, MA, United States

Although substantial progress has been made in deciphering genetic and histological events in cancers, metabolic rearrangements that provide building blocks to elicit uncontrolled proliferation in cancers is still not understood. Nucleotide and lipids are the basic units needed for cell proliferation and membrane synthesis. Our in vivo MRS studies at 3 T in glioma patients indicate that tumors rearrange glutamine metabolism to produce citrate for increased lipid biosynthesis for membrane formation, and nucleotide for cell-multiplication.

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