Although substantial progress has been made in deciphering genetic and histological events in cancers, metabolic rearrangements that provide building blocks to elicit uncontrolled proliferation in cancers is still not understood. Nucleotide and lipids are the basic units needed for cell proliferation and membrane synthesis. Our in vivo MRS studies at 3 T in glioma patients indicate that tumors rearrange glutamine metabolism to produce citrate for increased lipid biosynthesis for membrane formation, and nucleotide for cell-multiplication.
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