Abstract #0854

Low extracellular acidification in 1p/19q co-deleted gliomas confirmed using pH-weighted amine CEST-EPI, T2 relaxometry, and amino acid PET

Jingwen Yao^1,2,3, Ararat Chakhoyan^1,3, Catalina Raymond^1,3, Noriko Salamon³, Linda Liau^4,5, Phioanh Nghiemphu⁶, Albert Lai^5,6, Whitney Pope³, Timothy Cloughesy⁶, and Benjamin Ellingson^1,2,3,5,7,8

¹Brain Tumor Imaging Laboratory (BTIL), Center of Computer Vision and Imaging Biomarker, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ²Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA, United States, ³Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ⁴Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ⁵UCLA Brain Research Institute (BRI), David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ⁶Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ⁷Physics and Biology in Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ⁸Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States

The 1p/19q co-deletion in gliomas is associated with better response to therapies and better patient prognosis. In this study, we demonstrate that 1p/19q co-deleted gliomas are less acidic than gliomas with intact 1p/19q using a combination of pH-sensitive amine CEST-EPI, T₂ relaxometry, and ¹⁸F-FDOPA PET. Results suggest amine CEST-EPI may serve as a quick non-invasive imaging biomarker for identifying 1p/19q co-deleted tumors. Our results also support the hypothesis that the better prognosis and higher sensitivity to treatment of 1p/19q co-deleted gliomas may be related to less acidity in tumor microenvironment.

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