Biological aggressiveness of glioma extends beyond the radiological territory. Based on the atlas based method and diffusion metrics derived from diffusion tensor imaging, the remote effect of cerebral gliomas on the white matter connectivity was analyzed at the global level. LGGs and HGGs showed difference in the diffusion metrics in the contralesional brain regions with hemispheric and anatomical specifications, which possibly underlie the functional neuroplasticity confounding the aggressiveness assessment and management of glioma.
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