Deuterium Metabolic Imaging (DMI) is a novel approach providing high 3D spatial resolution metabolic data from both animal models and human subjects. DMI relies on 2H MRSI in combination with administration of 2H-labeled substrates. Here we describe the first experiences with using DMI to map steady state metabolism of orally administered [6,6’-2H2]-glucose in patients diagnosed with a brain tumor. DMI revealed striking image contrast based on regional differences of glucose metabolism, with high-grade tumor lesions depicting metabolite labeling with consistently high lactate production and low glucose oxidation, a metabolic phenotype known as the Warburg effect.
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