Abstract #0860

Serial characterization of HP [1-13C]pyruvate metabolism in the brains of patients with glioma and healthy controls

Adam W Autry¹, Jeremy W Gordon¹, Hsin-Yu Chen¹, Daniele W Mammoli¹, Marisa Lafontaine¹, Javier Villanueva-Meyer¹, Susan M Chang², Duan Xu¹, Peder EZ Larson¹, Daniel B Vigneron^1,3, Sarah J Nelson^1,3, and Yan Li¹

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States, ³Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States

Serial dynamic hyperpolarized [1-¹³C]pyruvate imaging was performed on 3 patients undergoing treatment for recurrent brain tumors and 2 healthy controls using a frequency-specific EPI sequence (20 total scans). To evaluate metabolism within normal-appearing white matter (NAWM), rate constants for pyruvate-to-lactate (k_PL) and pyruvate-to-bicarbonate (k_PB) conversion were kinetically modeled. Healthy control data provided reference rate constants in NAWM and demonstrated replicabililty of test-retest type scans across hardware platforms. Serial patient data also showed similar, replicable data with standard-of-care treatment, as well as evidence that k_{PL, NAWM} is increased 148-290% following administration of anti-angiogenic agent Bevacizumab, which promotes vascular normalization.

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