Aberrant Temporal Flexibility of Visual Network in Schizophrenia: a Resting State fMRI Study

Schizophrenia has been associated with large-scale hypo-connectivity between brain networks. Since functional connectivity (FC) is dynamic, characterizing the temporal dynamics of FC may provide valuable insights regarding the underlying FC aberrance of patients. We present a framework to investigate the aberrant functional interaction between brain networks in schizophrenia using sliding window correlation and modularity analysis and found aberrant temporal flexibility in ROIs for visual object recognition in patients. Examination of their temporal co-activation profiles revealed higher co-activation of visual network with DMN, MEM and FPN in schizophrenia, indicating the patients might have active functional interaction between these systems under resting condition.