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Abstract #0883

Aberrant Resting-state Functional Connectivity of Cerebellar Vermis in Parkinson’s Disease

Li Jiang1, Brenda Hanna-Pladdy1, Jiachen Zhuo1, Paul Fisherman2, and Rao Gullapalli1

1University of Maryland Medical School, Baltimore, MD, United States, 2Department of Neurology, University of Maryland Medical School, Baltimore, MD, United States

Parkinson’s disease (PD) is one of the most common neurodegenerative disorder in the aging population1, characterized by progressive deterioration of motor function as well as non-motor symptoms2,3. To date, most of the resting-state fMRI PD studies focused on basal ganglia3,4,5, whereas few studies on cerebellum5,6, especially cerebellar vermis. In this study, we investigated the rs-FC difference in whole brain in PD patients compared with health controls and the association between FC of vermis and motor and neuropsychological measurements in PDs. Our results suggest that the cerebral vermis, visual cortex, and visual processing associated areas contribute to the development of symptoms in PD.

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