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Abstract #0887

Increased Functional Connectivity Flexibility During Early Infancy

Xuyun Wen1,2, Han Zhang2, Rifeng Wang2, Weili Lin2, and Dinggang Shen2

1School of Data and Computer Science, Sun-Yat Sen University, Guangzhou,Guangdong, China, 2Department of Radiology and BRIC, University of North Carolina at Chapel Hill, chapel hill, NC, United States

Understanding the nature of dynamic neural interactions during development is a critical issue of cognitive neuroscience. However, our knowledge on infants’ functional connectivity (FC) dynamics is still scarce. Leveraging longitudinal infant resting-state fMRI from fifty-one typically developing infants, we, for the first time, charted the development of dynamic functional networks in the first two postnatal years. The results show that many high-order cognitive function-related brain regions have significantly increased temporal variability in the FC patterns, suggesting that the brain network is gradually reconfigured towards a more flexible, dynamic, and adaptive system, which mirrors the rapidly developing complex functions in early infancy.

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