Abstract #0888

Maternal immune activation during pregnancy impacts on resting state functional connectivity in the adult offspring

Silke Kreitz¹, Alice Zambon², Marianne Ronovsky², Lubos Budinsky³, Thomas Helbich³, Spyros Sideromenos², Claudiu Ivan¹, Laura Christina Konerth¹, Isabel Wank¹, Angelika Berger⁴, Arnold Pollak⁴, Andreas Hess¹, and Daniela D. Pollak²

¹Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany, ²Department of Neurophysiology and Neuropharmacology, Medical University of Vienna, Vienna, Austria, ³Department of Biomedical Imaging and Image-Guided Therapy, Division of Molecular and Gender Imaging, Medical University of Vienna, Vienna, Austria, ⁴4Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria

The infection of the pregnant female and the ensuing induction of maternal immune activation affect fetal development with long-lasting consequences for health and disease. Specifically aberrant neural wiring may contribute in the manifestation of psychiatric disorders such as depression. Here, we investigated altered resting state functional connectivity using fMRI in adult mice after prenatal immune activation. While the overall flow of information was intact, especially the cortico-limbic connectivity was disrupted in resting state networks of adult offspring. We propose that these altered connectivity patterns may lead to behavioral and emotional abnormalities with relevance for neuropsychiatric disorders.

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