Abstract #0891

Structural brain network properties and cognitive impairment in adolescents after radiation therapy

Justin P Yuan¹, Melanie A Morrison¹, Angela Jakary¹, Sabine Mueller², Olga Tymofiyeva¹, Duan Xu¹, and Janine M Lupo¹

¹Department of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Department of Neurology, University of California, San Francisco, San Francisco, CA, United States

Cranial radiation therapy (CRT) is an effective brain cancer treatment but many patients exhibit cognitive deficits over time. We studied these deficits in adolescent and young adult survivors of pediatric brain cancer with prior CRT using white matter graph network analysis. Executive function and working memory performance were correlated with structural connectivity metrics. Global integration and segregation metrics were associated with neurocognitive deficits, as well as connectivity at domain-specific regions. Our results support past findings of CRT’s negative cognitive effects and suggest that they are driven through structural changes in brain white matter

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