Differentiating treatment response from Glioblastoma progression with conventional proton magnetic resonance imaging (MRI) is challenging as it cannot unambiguously differentiate between early therapeutic response and treatment-related pseudo-progression. Based on the stability of sodium’s relaxation rate across human brains, a recent approach for separating motile and motion-restricted sodium ion pools (MRSIP) in the brain was introduced. In this study we evaluate the relationship between MRSIP concentration and the treatment evolution on a pool of glioma patients.
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