Abstract #0892

Motion-Restricted Sodium Ion Pools Analysis on Glioblastoma patients with Combinatorial Therapy

Xiuyuan Wang^1,2, Yongxian Qian^1,2, Rajan Jain^2,3, Andrew Chi^3,4, Sylvia Kurz⁴, and Fernando Boada^1,2

¹Center for Advanced Imaging Innovation and Research (CAI2R), NYU School of Medicine, New York, NY, United States, ²Center for Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, NY, United States, ³Department of Neurosurgery, NYU School of Medicine, New York, NY, United States, ⁴Department of Neurology, NYU School of Medicine, New York, NY, United States

Differentiating treatment response from Glioblastoma progression with conventional proton magnetic resonance imaging (MRI) is challenging as it cannot unambiguously differentiate between early therapeutic response and treatment-related pseudo-progression. Based on the stability of sodium’s relaxation rate across human brains, a recent approach for separating motile and motion-restricted sodium ion pools (MRSIP) in the brain was introduced. In this study we evaluate the relationship between MRSIP concentration and the treatment evolution on a pool of glioma patients.

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