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Abstract #0901

Voxelwise correlation between vascular parameters obtained with ASL and DSC as predictor of IDH-mutation status in non-enhancing glioma

Esther AH Warnert1, Fatih Incekara1,2, Arnaud JPE Vincent2, Joost W Schouten2, Martin J van den Bent3, Pim J French3, Hendrikus J Dubbink4, Johan M Kros4, Juan-Antonio Hernandez-Tamames1, and Marion Smits1

1Department of Radiology & Nuclear Medicine, Erasmus Medical Centre, Rotterdam, Netherlands, 2Department of Neurosurgery, Erasmus Medical Centre, Rotterdam, Netherlands, 3Department of Neurology, Erasmus MC, Rotterdam, Netherlands, 4Department of Pathology, Erasmus MC, Rotterdam, Netherlands

Previous studies have shown good correlation between ASL and DSC vascular parameters as predictors of glioma grade, indication an option to omit DSC imaging in light of the recent finding of gadolinium deposition in the brain. However, in general these comparative studies were conducted before the recent update of the World Health Organisation classification of brain tumours. This study shows the potential of voxelwise correlations of vascular parameters obtained with ASL and DSC as predictors of IDH-mutation status in non-enhancing glioma and highlights that IDH-mutation status should be included in comparative studies of ASL and DSC vascular parameters in glioma.

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