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Abstract #0902

Diffusion and quantitative MR changes in normal appearing brain following radiotherapy.

Felix Raschke1, Tim Wesemann2, Hannes Wahl2, Steffen Appold3, Mechthild Krause1,3,4,5,6, Jennifer Linn2, and Esther G. C. Troost1,3,4,5,6

1Institute of Radiooncology - OncoRay, Helmholtz-Zentrum Dresden-Rossendorf, Rossendorf, Germany, 2Institute of Neuroradiology, University Hospital Carl Gustav Carus and Medical Faculty of Technische Universität Dresden, Dresden, Germany, 3Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, 4OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany, 5National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and; Helmholtz Association / Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany, 6German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany

Irradiation of gliomas inevitably involves irradiation of surrounding normal appearing brain. We analysed longitudinal, quantitative MR data of 24 glioma patients before and at 3, 6, 9 and 12 months after radiotherapy and found significant reductions in mean-, axial- and radial diffusivity as well as in T2* in normal appearing white matter. These changes are greater the higher the received dose and progress over time. The diffusion reductions point towards axonal swelling. T2* reductions indicate either increased tissue heterogeneity, e.g. due to microglial activation or changes in tissue oxygenation, e.g. due to vascular alterations.

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