Abstract #0902

Diffusion and quantitative MR changes in normal appearing brain following radiotherapy.

Felix Raschke¹, Tim Wesemann², Hannes Wahl², Steffen Appold³, Mechthild Krause^1,3,4,5,6, Jennifer Linn², and Esther G. C. Troost^1,3,4,5,6

¹Institute of Radiooncology - OncoRay, Helmholtz-Zentrum Dresden-Rossendorf, Rossendorf, Germany, ²Institute of Neuroradiology, University Hospital Carl Gustav Carus and Medical Faculty of Technische Universität Dresden, Dresden, Germany, ³Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, ⁴OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany, ⁵National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and; Helmholtz Association / Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany, ⁶German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany

Irradiation of gliomas inevitably involves irradiation of surrounding normal appearing brain. We analysed longitudinal, quantitative MR data of 24 glioma patients before and at 3, 6, 9 and 12 months after radiotherapy and found significant reductions in mean-, axial- and radial diffusivity as well as in T2* in normal appearing white matter. These changes are greater the higher the received dose and progress over time. The diffusion reductions point towards axonal swelling. T2* reductions indicate either increased tissue heterogeneity, e.g. due to microglial activation or changes in tissue oxygenation, e.g. due to vascular alterations.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.