Abstract #0946

Rapid High-Resolution Simultaneous Acquisition of Metabolites, Myelin Water Fractions, and Tissue Susceptibility of the Whole Brain Using "SPICY" 1H-MRSI

Yudu Li^1,2, Rong Guo^1,2, Yibo Zhao^1,2, Tianyao Wang³, Ziyu Meng^4,5, Yao Li^4,5, and Zhi-Pei Liang^1,2

¹Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ²Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ³Department of Radiology, The Fifth People's Hospital of Shanghai, Shanghai, China, ⁴School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ⁵Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China

We report further advances on ultrahigh-resolution ¹H-MRSI without water suppression to enable rapid simultaneous acquisition of brain metabolites, myelin water fractions (MWF) and tissue susceptibility in high spatial resolution. Building on the SPICE (SPectroscopic Imaging by exploiting spatiospectral CorrElation) subspace imaging framework, we extend the SPICE data acquisition scheme with several novel features, including the use of ultrashort-TE (~1.6 ms), very-short-TR (~160 ms), and variable density sampling of (k, t)-space. We reconstruct the spatial distributions of brain metabolites, MWF, and tissue susceptibility using model-based reconstruction methods that incorporate learned spatiospectral features. Experimental results have been obtained which demonstrate that in a single 5-min scan, we can obtain metabolites in a nominal resolution of 2.0×2.4×3.0 mm³ and QSM/MWF in a nominal resolution of 1.8×1.8×1.8 mm³.

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